Canine malignant melanoma alpha-3 integrin binding peptides
نویسندگان
چکیده
منابع مشابه
Tumor targeting with radiolabeled alpha(v)beta(3) integrin binding peptides in a nude mouse model.
The alpha(v)beta(3) integrin is expressed on proliferating endothelial cells such as those present in growing tumors, as well as on tumor cells of various origin. Tumor-induced angiogenesis can be blocked in vivo by antagonizing the alpha(v)beta(3) integrin with small peptides containing the Arg-Gly-Asp (RGD) amino acid sequence. This tripeptidic sequence, naturally present in extracellular mat...
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The skeletal dysplasias are disorders of the bone and cartilage tissues. Similarly to humans, several dog breeds have been reported to suffer from different types of genetic skeletal disorders. We have studied the molecular genetic background of an autosomal recessive chondrodysplasia that affects the Norwegian Elkhound and Karelian Bear Dog breeds. The affected dogs suffer from disproportionat...
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Since tumor progression is dependent on the ability of malignant cells to interact with the extracellular matrix, molecules on the cell surface which mediate cell-substratum interactions are likely to be important regulators of tumor invasion and metastasis. The purpose of this study was to examine the distribution of one such group of cell adhesion receptors, the integrins, in benign and malig...
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ژورنال
عنوان ژورنال: Veterinary Immunology and Immunopathology
سال: 2011
ISSN: 0165-2427
DOI: 10.1016/j.vetimm.2011.05.018